Re-epithelialization: advancing epithelium frontier during wound healing
نویسندگان
چکیده
منابع مشابه
Re-epithelialization: advancing epithelium frontier during wound healing
The first function of the skin is to serve as a protective barrier against the environment. Its loss of integrity as a result of injury or illness may lead to a major disability and the first goal of healing is wound closure involving many biological processes for repair and tissue regeneration. In vivo wound healing has four phases, one of them being the migration of the healthy epithelium sur...
متن کاملWound re-epithelialization: modulating keratinocyte migration in wound healing.
An essential feature of a healed wound is the restoration of an intact epidermal barrier through wound epithelialization, also known as re-epithelialization. The directed migration of keratinocytes is critical to wound epithelialization and defects in this function are associated with the clinical phenotype of chronic non-healing wounds. A complex balance of signaling factors and surface protei...
متن کاملDelayed Re-Epithelialization in Periostin-Deficient Mice during Cutaneous Wound Healing
BACKGROUND Matricellular proteins, including periostin, are important for tissue regeneration. METHODS AND FINDINGS Presently we investigated the function of periostin in cutaneous wound healing by using periostin-deficient ⁻/⁻ mice. Periostin mRNA was expressed in both the epidermis and hair follicles, and periostin protein was located at the basement membrane in the hair follicles together ...
متن کاملmiR-21 Promotes Keratinocyte Migration and Re-epithelialization during Wound Healing
MicroRNAs involved in keratinocyte migration and wound healing are largely unknown. Here, we revealed the indispensable role of miR-21 in keratinocyte migration and in re-epithelialization during wound healing in mice. In HaCaT cell, miR-21 could be upregulated by TGF-β1. Similar to the effect of TGF-β1, miR-21 overexpression promoted keratinocyte migration. Conversely, miR-21 knockdown attenua...
متن کاملEpithelialization in Wound Healing: A Comprehensive Review.
Significance: Keratinocytes, a major cellular component of the epidermis, are responsible for restoring the epidermis after injury through a process termed epithelialization. This review will focus on the pivotal role of keratinocytes in epithelialization, including cellular processes and mechanisms of their regulation during re-epithelialization, and their cross talk with other cell types part...
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ژورنال
عنوان ژورنال: Journal of The Royal Society Interface
سال: 2014
ISSN: 1742-5689,1742-5662
DOI: 10.1098/rsif.2013.1038